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Subject: Acute versus Gradual Switch From Pramipexole to Ropinirole (MovDis Congress 2000) Date: 6/23/2000 E-MOVE reports from the 6th International Congress of Parkinson's Disease and Movement Disorders, held in Barcelona, Spain, 11-15 June 2000. Citation numbers refer to abstract numbers published in Movement Disorders 2000;15 (Supplement 3).Acute versus gradual pramipexole to ropinirole switch R Hauser, C Reider, M Stacy, J Hubble, LC Seeberger, L Gauger, K Williamson, C Dingmann, R Rice, SP Krulwicz, R Zaninelli P 681 Forty-eight PD patients with motor fluctuations taking a mean of 2.5 mg/day pramipexole and concomitant levodopa were randomized to switch to ropinirole either overnight or gradually over 3 weeks. Dose equivalence used was 1 pramipexole=3 ropinirole. Three gradual and two acute patients withdrew prior to the 3-week evaluation. At week 3, 71% of the gradual group versus 46% of the acute group tolerated the switch with no or only mild difficulty (p=0.14), as determined by self-report, indicating the gradual switch "tended to be better tolerated." Seventy- one percent of the gradual group and 86% of the acute group reported deterioration in their motor status. Following the 3-week evaluation, ropinirole could be increased. At week 6, mean dose of ropinirole for all patients was 8.92 mg, suggesting a dose equivalence of 1 pramipexole=3.8 ropinirole. E-MOVE Editor: Richard Robinson, NASW, WE MOVE
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