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Subject: Permanganate-Induced Parkinsonism; Spinal Cord Pathology in PSP (WCN 2001) Date: 7/3/2001 E-MOVE reports from the 17th World Congress of Neurology, London, June 17-22. Poster and Platform session numbers refer to those in the abstract book, published in Journal of the Neurological Sciences 2001;187 (supplement 1).1. A new source of chronic manganese intoxication: Substance abuse S Baybas, A Koksal, V Sozmen, C Dayan, A Ceyhan, A Dincer S68.05 Four male patients developed parkinsonism from chronic intravenous injection of ephedrine, salicylate, and potassium permanganate. Over 2-6 years, the daily dose of Mn was 17-512 mg. Blood MN was elevated 3-10 fold. Symptoms emerged at 6 months to 4 years, with bradykinesia, gait disturbance, postural tremor, ataxia, and dyskinesia. Cranial MRI revealed T1 hyperintensity at several regions in the basal ganglia in three patients. In one patient who was imaged 28 months after stopping injection, hyperintensity was seen only in the Gpi. 2. Spinal cord involvement in progressive supranuclear palsy R Vitaliani, T Scaravilli, PP Pramstaller, B Tavolato, B Giometto, F Scaravilli P0933 PSP causes degeneration throughout the spinal cord, according to this report. Spinal cords from 5 PSP patients were compared to 3 controls. Tau-positive inclusions were found at all levels and in all laminae. Motor neuron loss was 45% at the cervical level, 47% at the thoracic level, and 32% at the lumbar level (all p<0.001). --- Funding for E-MOVE meeting reports is provided in part by unrestricted educational grants from Allergan Inc., Elan Pharmaceuticals, and Pharmacia Corporation. E-MOVE Editor: Richard Robinson, NASW, WE MOVE
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