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Dystonia
Botulinum Toxin Type B for Dystonia On December 11, 2000, a botulinum toxin type B product, Myobloc™ (rimabotulinumtoxinB) was approved by the FDA in the United States as a treatment for patients with cervical dystonia. Myobloc™ is the U.S. trade name for Solstice Neurosciences' botulinum toxin type B product. This product also received marketing authorization from the European Union's Committee for Proprietary Medicinal Products and is available there as Neurobloc®. Safety and efficacy were demonstrated in double-blind clinical trials in patients who had responded to BoNT-A and in patients who had developed resistance to BoNT-A. BoNT-A and BoNT-B have slightly different chemical structures and their primary mechanisms of action on acetylcholine also differ. The appropriateness of BoNT-B–or of any dystonia therapy–relies on its ability to meet the goals of patients and caregivers as outlined in their comprehensive treatment plan. See E-MOVE Article: BoNT-B for cervical dystonia (AAN report)
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