Parkinson's Disease

Amantadine

Amantadine (Symmetrel®, generics) has a mild symptomatic effect on the motor symptoms of PD, but a more significant effect on the reduction of dyskinesias. It is believed to act through blockade of N-methyl-D-aspartate (NMDA) receptors. It is usually dosed at 100 mg 2-4 times per day. Side effects include hallucinations, insomnia, agitation, and difficulty concentrating, as well as ankle edema, dry mouth and mottled skin. Amantadine may be ineffective for dyskinesias in up to one third of patients.