Five classes of drugs comprise the pharmacological armamentarium for the motor symptoms of PD:
| Dopaminergic agents |
| Levodopa/carbidopa (Sinemet®, generics, Parcopa® orally disintegrating tablet) |
| Dopamine agonists |
| Apomorphine (Apokyn®) |
| Bromocriptine (Parlodel®) |
| Cabergoline (Not approved in the US) |
| Lisuride (Not approved in the US) |
| Pergolide (Permax®; withdrawn from US market March 2007) |
| Pramipexole (Mirapex®) |
| Ropinirole (Requip®) |
| Rotigotine (Neupro® patch) |
| |
| COMT Inhibitors |
| Entacapone (Comtan®, Stalevo®) |
| Tolcapone (Tasmar®) |
| |
| MAO-B Inhibitors |
| Rasagiline (Azilect®) |
| Selegiline (Eldepryl® orally swallowed pill, Zelapar® orally disintegrating tablet) |
| |
| Anticholinergics |
| Trihexyphenidyl (Artane®) |
| Benztropine |
| Ethopropazine |
| |
| Amantadine (Symmetrel®, generics) |
