Pediatric Movement Disorders - Treatments

Baclofen

Baclofen (Lioresal®) activates the GABA type B receptors that are found in the spinal cord. As a result, it is particularly useful in spasticity. Baclofen can be administered by mouth, but it may also be given by continuous pump infusion into the spinal cord. This is delivered through a plastic catheter, which is inserted by a surgeon. The baclofen pump reduces the side effects, which are primarily drowsiness. Like trihexyphenidyl, baclofen often must be taken in large doses; the dose must be slowly increased in order to minimize side effects.